Article

Generating Potential Protein-Protein Interaction Inhibitor Molecules Based on Physicochemical Properties

2023-06-30

Abstract excerpt

Protein-protein interactions (PPIs) are associated with various diseases; hence, they are important targets in drug discovery. However, the physicochemical empirical properties of PPI-targeted drugs are distinct from those of conventional small molecule oral pharmaceuticals, which adhere to the ”rule of five (RO5).” Therefore, developing PPI-targeted drugs using conventional methods, such as molecular...

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Literature Corpus work: 71f7c772-9238-5e3d-9d32-a18b63cd90f5
DOI: 10.20944/preprints202305.0704.v2

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