Article

SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals

2020-05-01

Abstract excerpt

SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To p...

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Literature Corpus work: 71f0797c-453c-53cd-80af-80400aeb0413
DOI: 10.1101/2020.05.01.072371

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