Article

Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling

2024-03-29

Abstract excerpt

Autophagy-lysosomal degradation is an evolutionarily conserved process key to cellular homeostasis, differentiation, and stress survival, which is particularly important for the cardiovascular system. Furthermore, experimental and clinical observations indicate it affects cardiac morphogenesis, including valve development. However, the cell-specificity and functional role of autophagic processes during heart devel...

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Literature Corpus work: 71dc6006-6c03-5706-8364-5f56c80ad2c8
DOI: 10.1101/2024.03.26.586825

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