Article

A Novel Mouse Model for <i>LAMA2</i> -Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype

2024-01-06

Abstract excerpt

Our understanding of the molecular pathogenesis of LAMA2 -related muscular dystrophy ( LAMA2 -MD) requires improving. Here, we report the phenotype, neuropathology and transcriptomics data (scRNA-seq and bulk RNA-seq) of a new Lama2 knockout mouse (dy H /dy H ) which was created based on the human LAMA2 -MD mutation hotspot region using CRISPR-Cas9. The dy H /dy H mice presented severe phenotype with muscu...

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Literature Corpus work: 70d1c742-8a92-5435-870e-78108bdcae8a
DOI: 10.1101/2024.01.06.574440

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