Article

A recurrent MCF2 variant which disrupts DCC binding leads to congenital mirror movements and corpus callosum agenesis

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>Neuronal wiring in the developing nervous system relies on axon guidance, a process which enables proper axon pathfinding to target cells. Disruption of axon guidance results in a wide spectrum of defects including congenital mirror movements (CMM) and corpus callosum agenesis (CCA). Axon guidance signaling pathways, such as Netrin-1/DCC, act through guanine nucleotide exchange factors...

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Literature Corpus work: a0cd779b-3f3e-542d-8093-1ab4758c3de3
DOI: 10.21203/rs.3.rs-5227743/v1

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