Article

Novel three-dimensional live skin-like in vitro composite for safety tests

2023-05-10

Abstract excerpt

We describe the construction of novel three-dimensional (3D) skin-like cultures of spontaneously immortalised normal keratinocytes derived from human HaCaT cells using a non-woven membrane of silica fibre in differentiation medium. Analyses of skin differentiation markers in a 3D-skin-like in vitro composite (SLIC) revealed the expression of keratin 2, keratin 10, filaggrin, and involucrin, indicating mature skin...

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Literature Corpus work: 7008386e-8063-5d82-8918-30328b5c7242
DOI: 10.21203/rs.3.rs-2856804/v1

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