The role of hub neurons in modulating cortical dynamics

Abstract excerpt

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well understood. To start addressing this question we used the most up-to-date biologically-realistic dense neocortical microcircuit (NMC) of rodent, which has reconstruc...

Topics

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• Central Nervous System
• Electrophysiological Phenomena
• Gene Expression Profiling
• Neurons
• Single-Cell Analysis
• Transcription Factors
• Transcription, Genetic
• Transcriptome

Identifiers and source

Literature Corpus work

6fdef8c0-59a3-5bbf-a94f-a50fcfd78c63

DOI

10.1101/2021.06.11.448003