Back to search

Article

Chronic <i>Staphylococcus aureus</i> lung infection correlates with proteogenomic and metabolic adaptations leading to an increased intracellular persistence

2018-09-11

Abstract excerpt

<h4>Background</h4> Chronic lung infection of cystic fibrosis (CF) patients by Staphylococcus aureus is a well-established epidemiological fact. Indeed, S. aureus is the most commonly identified pathogen in the lungs of CF patients. Strikingly the molecular mechanisms underlying S. aureus persistency are not understood. <h4>Methods</h4> We selected pairs of sequential S. aureus isolates from 3 patients with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6fd15955-6c8b-5ef8-99ae-596a49d92a23
DOI
10.1101/414409
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chronic <i>Staphylococcus aureus</i> lung infection correlates with proteogenomic and metabolic adaptations leading to an increased intracellular persistenceDOI 10.1101/414409
Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular PersistenceSemantic proximity
Transcriptional adaptations during long-term persistence of Staphylococcus aureus in the airways of a cystic fibrosis patientSemantic proximity
Long-term intrahost evolution of methicillin resistant <i>Staphylococcus aureus</i> among cystic fibrosis patients with respiratory carriageSemantic proximity
How long does it take to cue a <i>Pseudomonas aeruginosa</i> chronic infection phenotype in the lab? Insights from transcriptome analysis in a cystic fibrosis lung modelSemantic proximity
Long-term adaptation to hypoxia provides insight into mechanisms facilitating the switch of <i>Pseudomonas aeruginosa</i> to chronic lung infectionsSemantic proximity
Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation.Semantic proximity
Microenvironment-driven phenotypic shifts in <i>Staphylococcus aureus</i> from children with cystic fibrosis: a longitudinal cohort studySemantic proximity
The Intra-Host Evolutionary Landscape And Pathoadaptation Of Persistent <i>Staphylococcus aureus</i> In Chronic RhinosinusitisSemantic proximity
From colonisation to chronicity: adaptation of <i>Mycobacterium abscessus</i> in the cystic fibrosis lung environmentSemantic proximity
Coexistence with <i>Pseudomonas aeruginosa</i> alters <i>Staphylococcus aureus</i> transcriptome, antibiotic resistance and internalization into epithelial cellsSemantic proximity
Long-Term Intrahost Evolution of Methicillin Resistant Staphylococcus aureus Among Cystic Fibrosis Patients With Respiratory CarriageSemantic proximity
Population Dynamics of Persistent <i>Staphylococcus aureus</i> Isolated from the Airways of Cystic Fibrosis Patients during a 6-Year Prospective StudySemantic proximity
Select a neighboring publication to make it the new centre.