Article

Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis

2020-04-13

Abstract excerpt

<title>Abstract</title> <p>Background Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of endothelial origin that closely resembles visceral angiosarcoma in humans, both clinically and histopathologically. Currently there is an unmet need for new diagnostics and therapies for both forms of this disease. The goal of this study was to utilize ChRO-seq and immunohistochemistry (IHC) to identify ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ef04fb4-33d2-5e3c-aa42-085dce6a9505
DOI: 10.21203/rs.2.20379/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesisDOI 10.21203/rs.2.20379/v2Read

Identification of genomic alterations with clinical impact in canine splenic hemangiosarcomaSemantic proximity Read

Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.Semantic proximity Read

Identification of genomic alterations with clinical impact in canine splenic hemangiosarcomaSemantic proximity Read

Real-world evidence couples genomic biomarkers with therapeutic outcomes for canine hemangiosarcomaSemantic proximity Read

Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma.Semantic proximity Read

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patientsSemantic proximity Read

Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humansSemantic proximity Read

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human AngiosarcomaSemantic proximity Read

Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic TargetsSemantic proximity Read

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future PerspectivesSemantic proximity Read

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients.Semantic proximity Read