Article

The Sparse Matrix of Drug Discovery: Sex, Race, and a Genomic Equity Index Across 40.8 Million Patients in 77,770 Clinical Trials

2026-05-19

Abstract excerpt

Demographic representation in clinical trials and downstream genomic databases has been documented to be skewed across two decades, but the structural origin of the skew remains contested. Here we test whether a single upstream protocol-writing bias drives demographic skew on both axes (race and sex) at the population scale of clinical-trial enrollment, and whether the same skew compounds at the genomic-database l...

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Literature Corpus work: 6ed3b737-d301-54d5-b7fe-a8e3ba9d5488
DOI: 10.64898/2026.05.14.26353197

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