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Molecular insights into inhibitor action on a key bacterial metabolic enzyme Cystathionine β-Synthase

2025-07-05

Abstract excerpt

Tuberculosis (TB) remains a major global health threat, with Mycobacterium tuberculosis (Mtb) infecting nearly a quarter of the global population. Drug-resistant TB and HIV-TB co-infections emphasize the need for novel therapeutic approaches targeting essential metabolic pathways. Here, we investigated Mtb cystathionine β-synthase (MtbCBS), a PLP-dependent enzyme critical for sulfur metabolism and redox regulation...

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Literature Corpus work
6eb510e5-76b4-54e8-9a58-f25b002858ff
DOI
10.1101/2025.07.03.662948
Open publication

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Molecular insights into inhibitor action on a key bacterial metabolic enzyme Cystathionine β-SynthaseDOI 10.1101/2025.07.03.662948
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