Article

Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism

2024-05-02

Abstract excerpt

Primary aldosteronism (PA) is the most common form of secondary hypertension. Major advances have been made in our understanding of PA with the identification of germline and somatic mutations in ion pumps and channels. These mutations lead to the activation of calcium signalling, the major trigger of aldosterone biosynthesis. To elucidate the molecular mechanisms underlying the development of PA, we established a...

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Literature Corpus work: 6e795854-4335-54d2-ad49-2571061f4ed7
DOI: 10.1101/2024.04.29.591306

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