Article

Frequency Mismatch Critically Limits Gamma Entrainment: A Kuramoto Model Study Supporting Personalized GENUS Therapy

2026-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Gamma oscillations (30–100 Hz) are critical for cognitive processing, and their disruption is associated with Alzheimer’s disease (AD) and related dementias. Gamma ENtrainment Using Sensory Stimulation (GENUS) therapy applies 40 Hz light and/or sound to restore gamma oscillations, but clinical trials report highly variable responses. Using Kuramoto oscillator models calibrated to human neurophys...

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Literature Corpus work: 6d924d64-f8fa-5d5d-aaee-8c800f3d9898
DOI: 10.64898/2026.04.28.26351909

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