Article

GPTAnno: Ontology-tree-guided hierarchical cell type annotation based on GPT models for single-cell data

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Cell type annotation is critical for interpreting single-cell transcriptomic data but remains challenging due to uncertain cellular clustering granularity and inconsistent labeling across studies. Here we present GPTAnno, an automated, ontology-tree-guided, uncertainty-aware, hierarchical cell type annotation method based on GPT models. GPTAnno directly handles gene expression matrices, integrat...

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Literature Corpus work: 6c6d2531-7645-51e5-bdc1-617bdf8ae084
DOI: 10.1101/2025.11.27.690951

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