Article

Species-specific small models for cell type classification approach the performance of large single cell foundation models

2026-03-18

Abstract excerpt

Accurate cross-species cell type classification remains a key evaluation task in single-cell transcriptomics. Recent foundation models trained on millions of single-cell profiles demonstrate great in-distribution and out-of-distribution performance on this task, but their large parameter counts and substantial computational costs limit accessibility and interpretability. Here, we introduce CytoType, a simple and i...

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Literature Corpus work: 6e5304a0-5235-5711-8d6c-f09607fa682b
DOI: 10.64898/2026.03.16.711196

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