Article

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

2014-12-24

Abstract excerpt

As next-generation sequencing becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Through the International Cancer Genome Consortium (ICGC), we compared sequencing pipelines at five independent centers (CNAG, DKFZ, OICR, RIKEN and WTSI) using a single tumor-blood DNA pair. Analyses by each center and with one standardized algorithm revealed significant d...

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Literature Corpus work: 6bdf7811-7a66-52e6-9204-192b2c439135
DOI: 10.1101/013177

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