Article
Framework for quality assessment of whole genome cancer sequences.
Nature communications - 7 Oct 2020
Whalley Justin P, Buchhalter Ivo, Rheinbay Esther, Raine Keiran M, Stobbe Miranda D, Kleinheinz Kortine, Werner Johannes, Beltran Sergi, Gut Marta, Hübschmann Daniel, Hutter Barbara, Livitz Dimitri, Perry Marc D, Rosenberg Mara, Saksena Gordon, Trotta Jean-Rémi, Eils Roland, Gerhard Daniela S, Campbell Peter J, Schlesner Matthias, Gut Ivo G
Abstract excerpt
Bringing together cancer genomes from different projects increases power and allows the investigation of pan-cancer, molecular mechanisms. However, working with whole genomes sequenced over several years in different sequencing centres requires a framework to compare the quality of these sequences. We used the Pan-Cancer Analysis of Whole Genomes cohort as a test case to construct such a framework. This cohort...
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