Article

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in <i>KRAS/p53</i> mutant lung cancers

2020-06-07

Abstract excerpt

Understanding resistance mechanisms to targeted therapies and immune checkpoint blockade in mutant KRAS lung cancers is critical to developing novel combination therapies and improving patient survival. Here, we show that MEK inhibition enhanced PD-L1 expression while PD-L1 blockade upregulated MAPK signaling in mutant KRAS lung tumors. Combined MEK inhibition with anti-PD-L1 synergistically reduced lung tumor gro...

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Literature Corpus work: 6bca131f-449c-5722-ba4d-1fb084989b1b
DOI: 10.1101/2020.06.07.136366

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