Article

A detailed methodology for developing and applying a 3D polyHIPE scaffold to model myeloma cell dormancy in vitro

2026-05-14

Abstract excerpt

Background Multiple myeloma is characterised by the outgrowth of malignant plasma cells in the bone marrow (BM). Disease relapse is driven by the reactivation of dormant myeloma cells (DMCs) that interact with osteoblastic lineage cells within the BM to evade therapy. Current two-dimensional (2D) in vitro culture systems lack the physiological and spatial complexity to replicate the BM microenvironment, while ani...

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Literature Corpus work: 6a6d473c-252c-5d01-acc8-605815e3c3cc
DOI: 10.12688/f1000research.178400.1

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