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Article

Modeling multiple myeloma-bone marrow interactions and response to drugs in a 3D surrogate microenvironment

11 Jan 2018

Abstract excerpt

Multiple myeloma develops primarily inside the bone marrow microenvironment, that confers pro-survival signals and drug resistance. 3D cultures that reproduce multiple myeloma-bone marrow interactions are needed to fully investigate multiple myeloma pathogenesis and response to drugs. To this purpose, we exploited the 3D Rotary Cell Culture System bioreactor technology for myeloma-bone marrow co-cultures in...

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PMID: 29326121
DOI: 10.3324/haematol.2017.167486

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