Article

Polygenic risk scores and Mendelian randomization reveal circadian genetic contributions to idiopathic hypersomnia

2026-01-06

Abstract excerpt

Idiopathic hypersomnia (IH) is a rare and heterogeneous sleep disorder characterized by excessive daytime sleepiness. We aimed to stratify IH patients based on polygenic risk scores (PRSs) for sleep-related traits and explored the underlying genetic predispositions. Genome-wide single-nucleotide polymorphism data from 303 Japanese IH patients and 2,918 controls were analyzed. PRSs were calculated for chronotype (m...

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Literature Corpus work: 6a220393-a73d-5978-8980-8f2ff3237a76
DOI: 10.64898/2026.01.06.26343504

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