Article
High-yield bioproduction of virus-free virus-like P4-EKORhE multi-lysin transducing particles as an antimicrobial gene therapeutic
2025-01-18
Abstract excerpt
A description of the construction of the bioengineered P4-EKORhE and a comprehensive method for producing very high yields (up to 10 12 particles per millilitre) enable the use of virus-like particles to transduce genetically encoded antimicrobials through a combination of synthetic biology and optimised upstream and downstream processing. The final product, a gene-delivered antimicrobial in the form of the multi...
Topics
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- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- CRISPR and Genetic Engineering
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
Identifiers and source
- Literature Corpus work
- 6a060fdc-2849-51c8-a00c-5dccbfa3e200
- DOI
- 10.1101/2025.01.15.633220