Article

Targeting multidrug-resistant bacteria with genetic-information-free protein-only phages

2025-10-15

Abstract excerpt

Bacteriophages offer advantages over small-molecule antibiotics, including host specificity and general compatibility with the human phagenome. However, their evolvability as replicating biological entities introduces therapeutic unpredictability and risks of phage-bacteria co-evolution. Here, we retain the targeting benefits of phages while avoiding genetic replication by engineering genetic-information-free, pro...

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Literature Corpus work: 984ae16d-65e9-549f-a1df-6a9023b5bc95
DOI: 10.1101/2025.10.13.682247

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