Article

Relapse/refractory paediatric B-ALL case with CD19 - phenotype switching indicating the importance of appropriate diagnostics approach and targeted treatment adjustment – case report

2023-03-24

Abstract excerpt

<h4>Background: </h4> The case reported presents a rare CD19 − phenotype shift of acute lymphoblastic leukaemia clone during the course of relapse/refractory ALL in a paediatric patient. We explore possible reasons promoting CD19 negative cell selection, including discrete mutations and anti-CD19 treatment, which is gaining importance as targeted therapies such as blinatumomab enter standard treatment protocols. C...

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Literature Corpus work: 694db02f-ea16-54cf-8c59-52051ee0e0e9
DOI: 10.21203/rs.3.rs-2652188/v1

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