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Integrated In silico and 3D Spheroid Models Reveal Key Genes and MiRNAs Driving Cisplatin/5-FU Resistance and Metastatic Potential in Gastric Cancer

2026-03-06

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<title>Abstract</title> <p> <bold>Background</bold> : Gastric cancer is a leading cause of cancer mortality worldwide, driven largely by chemotherapy resistance and metastasis. Cisplatin and 5-fluorouracil are common first-line agents, but tumor adaptation limits long-term efficacy; the combined role of microRNAs in resistance and metastasis remains unclear. <bold>Methods</bold> : We integrated bioinformatics...

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Literature Corpus work
e15bf7b7-93b9-5afa-a10d-c0b01185515b
DOI
10.21203/rs.3.rs-8821810/v1
Open publication

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Integrated In silico and 3D Spheroid Models Reveal Key Genes and MiRNAs Driving Cisplatin/5-FU Resistance and Metastatic Potential in Gastric CancerDOI 10.21203/rs.3.rs-8821810/v1
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