Versatile and Portable Cas12a-mediated Detection of Antibiotic Resistance Markers

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic-resistant bacteria are spreading in clinical, industrial, and environmental ecosystems. The spreading dynamics to and from the environment are unknown, largely due to the lack of appropriate (robust, fast, low-cost) analytical assays. In this study, we developed C12a, a versatile molecular toolbox to detect genetic markers of antibiotic resistance using CRISPR/Cas12a. Biochemical char...

Topics

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• Anti-Bacterial Agents
• Biosensing Techniques
• CRISPR-Cas Systems
• Drug Resistance, Bacterial
• Helicobacter Infections
• Helicobacter pylori
• Levofloxacin
• Polymerase Chain Reaction

Identifiers and source

Literature Corpus work

68ddf9f0-4e40-5d32-abb0-91f025f63e15

DOI

10.1101/2024.11.14.623642