Modeling canine hemangiosarcoma progression using patient-derived 2.5D organoids and orthotopic xenografts

Abstract excerpt

<title>Abstract</title> <p> Dogs commonly suffer from hemangiosarcoma (HSA) similar to human angiosarcoma (AS). The lack of adequate insight into the pathogenesis of canine HSA leads to clinical treatment failure. Thus, developing relevant preclinical models is instrumental for understanding disease and discovering new treatment strategies. In this study, we successfully generated canine HSA 2.5D organoids from...

Topics

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• Dog Diseases
• Dogs
• Exome
• Exome Sequencing
• Genes, Neoplasm
• Hemangiosarcoma
• ras Proteins
• Vascular Tumors and Angiosarcomas

Identifiers and source

Literature Corpus work

68c6e563-6105-5bc2-b43e-2d0c346d1f0f

DOI

10.21203/rs.3.rs-8550766/v1