Article
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.
BMC cancer - 9 Nov 2010
Tamburini Beth A, Phang Tzu L, Fosmire Susan P, Scott Milcah C, Trapp Susan C, Duckett Megan M, Robinson Sally R, Slansky Jill E, Sharkey Leslie C, Cutter Gary R, Wojcieszyn John W, Bellgrau Donald, Gemmill Robert M, Hunter Lawrence E, Modiano Jaime F
Abstract excerpt
BACKGROUND: The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species. These factors could represent a constellation of heritable characteristics that promote transformation events and/or facilitate the establishment of a microenvironment that is conducive for survival of malignant blood vessel-forming cells....
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