Article

Immunologically Optimized Zmp1 Peptides Reveal a Translational Serological Biomarker Platform for Tuberculosis Diagnosis Across Disease Manifestations

2026-06-12

Abstract excerpt

Tuberculosis (TB) diagnosis remains challenging, particularly for extrapulmonary TB (EPTB), where invasive sampling, low bacillary burden, and suboptimal sensitivity of nucleic acid-based tests in peripheral specimens hinder timely detection. Here, we report an immunology-driven strategy for biomarker discovery and development of a peptide-based serological assay targeting Mycobacterium tuberculosis zinc metallop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68a2f837-5346-5581-8c04-d9f3c0702c4b
DOI: 10.64898/2026.06.11.26355355

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunologically Optimized Zmp1 Peptides Reveal a Translational Serological Biomarker Platform for Tuberculosis Diagnosis Across Disease ManifestationsDOI 10.64898/2026.06.11.26355355Read

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read

Predicting Immunogenic CD4+ T Cell Epitopes in Bacteria Using Antigen and Peptide FeaturesSemantic proximity Read

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine ProfilesSemantic proximity Read

CD38+CD27− on Mtb-specific CD4+ T cells distinguishes latent from active tuberculosisSemantic proximity Read

Human CD1c-autoreactive T-cells recognise Mycobacterium tuberculosis –infected antigen-presenting cells and display cytotoxic effector programmesSemantic proximity Read

Dynamic antibody responses to the Mycobacterium tuberculosis proteomeSemantic proximity Read

From simple to complex: Protein‐based biomarker discovery in tuberculosisSemantic proximity Read

A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussisSemantic proximity Read

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and bloodSemantic proximity Read

Identification of novel salivary candidate protein biomarkers for tuberculosis diagnosisSemantic proximity Read

A vaccine for global eradication of TB - A novel conceptual framework and design of a potent peptide-based vaccine with universal coverage through advanced computational vaccinologySemantic proximity Read

Epitope promiscuity and population coverage of Mycobacterium tuberculosis protein antigens in current subunit vaccines under development.Semantic proximity Read