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Exercise-related immune gene signature for hepatocellular carcinoma: machine learning and multi-omics analysis

20 Jun 2025

Abstract excerpt

Background: Exercise is known to regulate the immune system. However, its prognostic value in hepatocellular carcinoma (HCC) remains largely unknown. Objective: This study aims to construct a machine learning-based prognostic signature using exercise-related immune genes (EIGs) to predict prognosis in HCC. Methods: We obtained mRNA-seq and scRNA of HCC from GeneCards, GEO, TCGA and ICGC. EIG were obtained using...

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PMID: 40621461
DOI: 10.3389/fimmu.2025.1606711

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