Article

Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning

2024-05-05

Abstract excerpt

Proteins are inherently dynamic, and their conformational ensembles are functionally important in biology. Large-scale motions may govern protein structure–function relationship, and numerous transient but stable conformations of Intrinsically Disordered Proteins (IDPs) can play a crucial role in biological function. Investigating conformational ensembles to understand regulations and disease-related aggregations...

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Literature Corpus work: 6812d544-f15c-5757-87e6-43f594376504
DOI: 10.1101/2024.05.05.592587

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