Article

Single-cell characterization of skin response to a bite by West Nile virus-infected mosquito reveals fibroblast-mediated barrier to transmission

2026-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Cutaneous events at the mosquito bite site that determine orthoflavivirus transmission efficiency remain largely uncharacterized. Here, we report single-cell RNA-sequencing of skin from immunocompetent mice bitten by West Nile virus-infected mosquitoes, capturing early response at a critical transmission bottleneck. Fibroblasts were the dominant cells exposed to infectious saliva. While neutroph...

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Literature Corpus work: 665b167e-0815-572c-be78-addca511140e
DOI: 10.64898/2026.01.08.698384

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