Article

Tissue-specific cellular architecture shapes antiviral transcriptional programs in porcine PRRSV and ASFV infections

2026-03-18

Abstract excerpt

<title>Abstract</title> <p>Background Porcine reproductive and respiratory syndrome virus (PRRSV) and African swine fever virus (ASFV) cause severe disease in pigs and represent major threats to global swine production. Bulk transcriptomic analyses have been widely used to characterize host responses to these infections; however, interpretation of bulk RNA sequencing (RNA-seq) signals remains limited because tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6515011a-6130-55b5-b332-39547fd49d16
DOI: 10.21203/rs.3.rs-9077992/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific cellular architecture shapes antiviral transcriptional programs in porcine PRRSV and ASFV infectionsDOI 10.21203/rs.3.rs-9077992/v1Read

Porcine epidemic diarrhea virus infection promotes Peyer’s patch immune induction and epithelial defense via single-cell transcriptional reprogrammingSemantic proximity Read

Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infectionSemantic proximity Read

Integrated time-serial transcriptome networks reveal common innate and tissue-specific adaptive immune responses to PRRSV infectionSemantic proximity Read

Temporal dynamics of cytokine, leukocyte, and whole blood transcriptome profiles of pigs infected with African swine fever virusSemantic proximity Read

Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencingSemantic proximity Read

A single-cell immune atlas of primary and secondary lymphoid organs in pigsSemantic proximity Read

Understanding PRRSV Infection in Porcine Lung Based on Genome-Wide Transcriptome Response Identified by Deep SequencingSemantic proximity Read

The comprehensive transcriptomic atlas of porcine immune tissues and the early peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genesSemantic proximity Read

Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulenceSemantic proximity Read

Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolutionSemantic proximity Read

Single-Cell Transcriptomic and Chromatin Accessibility Atlas of Peripheral Blood Mononuclear Cells Reveal the Immune Cell Heterogeneity of PigsSemantic proximity Read

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lungSemantic proximity Read