Article

Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC–derived neurons

2024-10-15

Abstract excerpt

Transmembrane L1 cell adhesion molecule (L1CAM) is widely used as a marker to enrich for neuron-derived extracellular vesicles (EVs), especially in plasma. However, this approach lacks sufficient robust validation. This study aimed to assess whether human biofluids are indeed enriched for EVs, particularly neuron-derived EVs, by L1CAM immunoaffinity, utilizing multiple sources (plasma, CSF, conditioned media from...

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Literature Corpus work: 64bd416f-3ed8-5ef1-a829-3d9d6dfea398
DOI: 10.1101/2024.10.14.618132

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