Article

Do High-mobility Group Box 1 Gene Polymorphisms Affect the Incidence of Differentiation Syndrome in Acute Promyelocytic Leukemia?

2021-12-02

Abstract excerpt

<title>Abstract</title> <p>Differentiation syndrome (DS) is an inflammatory complication seen in some patients with acute promyelocytic leukemia (APL) undergoing differentiation therapy with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). It is unknown how DS occurs, but it is believed that it is caused by inflammatory cytokines release from differentiating leukemic cells. High mobility group box-1...

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Literature Corpus work: 6489e1f7-3493-5d7d-af50-af0a8c44c80c
DOI: 10.21203/rs.3.rs-1084766/v1

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