Article

Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder

2024-01-11

Abstract excerpt

<title>Abstract</title> <p>Despite initial therapeutic successes, most patients with non-small cell lung cancer (NSCLC) who carry the KRAS<sup>G12C</sup> mutation ultimately exhibit resistance to targeted treatments. To improve our comprehension of how acquired resistance develops, we present an unprecedented longitudinal case study profiling the transcriptome of peripheral blood mononuclear cells (PBMCs) over 5...

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Literature Corpus work: 642477b4-27e5-50b9-9f06-b7320e140d2c
DOI: 10.21203/rs.3.rs-3784362/v1

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