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A modified decision tree improves generalization across multiple brains proteomic data sets and reveals the role of ferroptosis in Alzheimer’s disease

2024-08-07

Abstract excerpt

Low generalization to the patient cohort and variety of experimental conditions in the proteomic search for disease biomarkers are among the main reasons for the bumpy road of quantitative proteomics from discovery stage to clinical validation. Only a small fraction of biomarkers discovered so far by proteomic analysis reaches clinical trials. Here, we presented a machine learning-based workflow for proteomics dat...

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Literature Corpus work
636daeeb-09e9-58b1-8d38-46475150ed89
DOI
10.1101/2024.08.07.606974
Open publication

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A modified decision tree improves generalization across multiple brains proteomic data sets and reveals the role of ferroptosis in Alzheimer’s diseaseDOI 10.1101/2024.08.07.606974
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