Article
Accurate MS-Based Diagnostic Amyloid Typing Using Endogenously Normalized Protein Intensities in Formalin-Fixed Paraffin-Embedded Tissue
21 Jul 2025
Abstract excerpt
Amyloidoses are a group of diseases characterized by the pathological deposition of non-degradable misfolded protein fibrils. These include plasma cell neoplasms, chronic inflammatory conditions, and age-related disorders, among others. Precise identification of the fibril-forming, and thereby amyloidosis-type defining protein is crucial for prognosis and correct therapeutic intervention. While...
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