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Decoding the GPRC5A Paradox in Pancreatic Ductal Adenocarcinoma:A Subtype-Stratified, Treatment-Deconfounded, Multi-Omic Investigation

2026-03-31

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Pancreatic ductal adenocarcinoma (PDAC) carries a five-year survival rate below 10%, underscoring the urgent need for mechanistically grounded prognostic biomarkers. A prior batch-harmonized machine learning framework identified GPRC5A as prognostically relevant in PDAC but found reduced expression in deceased patients, the opposite of its established oncogen...

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Literature Corpus work
62cf71de-ea59-57bf-a747-96c3b6bb5560
DOI
10.21203/rs.3.rs-9237732/v1
Open publication

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Decoding the GPRC5A Paradox in Pancreatic Ductal Adenocarcinoma:A Subtype-Stratified, Treatment-Deconfounded, Multi-Omic InvestigationDOI 10.21203/rs.3.rs-9237732/v1
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