Article
Drug resistance prediction for <i>Mycobacterium tuberculosis</i> with reference graphs
2023-05-04
Abstract excerpt
2. The dominant paradigm for analysing genetic variation relies on a central idea: all genomes in a species can be described as minor differences from a single reference genome. However, this approach can be problematic or inadequate for bacteria, where there can be significant sequence divergence within a species. Reference graphs are an emerging solution to the reference bias issues implicit in the “single-refer...
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Identifiers and source
- Literature Corpus work
- 62b74ef1-7309-5b54-a598-221d89b69e0f
- DOI
- 10.1101/2023.05.04.539481