Article

Mutual information analysis of mutation, nonlinearity and triple interactions in proteins

2022-05-14

Abstract excerpt

Mutations are the cause of several diseases as well as the underlying force of evolution. A thorough understanding of its biophysical consequences is essential. We present a computational framework for evaluating different levels of mutual information (MI) and its dependence on mutation. We used molecular dynamics trajectories of the third PDZ domain and its different mutations. MI calculated from these trajectori...

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Literature Corpus work: 61857444-9af1-571e-8d90-359ae50eab52
DOI: 10.22541/au.165249903.30149447/v1

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