Article

Predicting Cavg of CFTR Modulators Using Sparse Sampling: Evaluating Single and Multiple Time Points with Machine Learning Approaches

2025-06-12

Abstract excerpt

<h4>Background: </h4> Cystic fibrosis (CF) is caused by genetic variants in the CFTR gene, which causes a defective chloride channel and impaired chloride and water transport. CFTR modulators, including elexacaftor, tezacaftor, and ivacaftor (ETI), improved clinical outcomes by correcting the underlying defect in the CFTR protein. Pharmacokinetic parameters such the average concentration (Cavg) is useful for optim...

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Literature Corpus work: 613fd073-c3e6-52e7-96ec-81d11a404836
DOI: 10.22541/au.174973419.93224560/v1

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