Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone mesenchymal stem cells improve cholestatic liver fibrosis by targeting ULK1 to regulate autophagy through PI3K/AKT/mTOR pathway

13 May 2024

Abstract excerpt

Cholestatic liver disease (CLD) is a severe disease, which can progress to liver cirrhosis, even liver cancer. Hepatic stellate cells (HSCs) activation plays a crucial role in CLD development. Bone mesenchymal stem cells (BMSCs) treatment was demonstrated to be beneficial in liver diseases. However, the therapeutic effect and mechanism of BMSCs on CLD are poorly known. In the present study, we investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Liver physiology and pathology
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38736295
DOI: 10.1093/stcltm/szae028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone mesenchymal stem cells improve cholestatic liver fibrosis by targeting ULK1 to regulate autophagy through PI3K/AKT/mTOR pathwayPMID 38736295Read ↗

Molecular Mechanisms of Fibrosis in Cholestatic Liver Diseases and Regenerative Medicine-Based TherapiesSemantic proximity Read ↗

Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapySemantic proximity Read ↗

Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathwaySemantic proximity Read ↗

Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human DiseasesSemantic proximity Read ↗

Mesenchymal stem cells improve liver fibrosis and protect hepatocytes by promoting microRNA-148a-5p mediated inhibition of Notch signaling pathwaySemantic proximity Read ↗

Transcriptome analysis of hepatic fibrosis induced by common bile duct ligationSemantic proximity Read ↗

Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)Semantic proximity Read ↗

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Regulating Choline Metabolism and PI3K/Akt/mTOR PathwaySemantic proximity Read ↗

Wnt signaling in biliary development, proliferation, and fibrosisSemantic proximity Read ↗

Cell therapy for liver diseases: current medicine and future promises.Semantic proximity Read ↗

MicroRNA-21/PTEN/Akt axis in the fibrogenesis of biliary atresiaSemantic proximity Read ↗

Tomatidine improves liver fibrosis by promoting autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.