Article

Luteolin attenuate paraquat-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway

2024-07-23

Abstract excerpt

<title>Abstract</title> <p>Acute lung injury (ALI) is the primary cause of death in patients who are affected by paraquat (PQ) poisoning. Luteolin (Lut) is a flavone compound present in several medicinal plants. The present study aimed to explore the protective role of Lut in PQ-induced ALI and the underlying molecular mechanisms. Network pharmacology analysis was used to predict key genes and signaling pathways...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 600f562f-ec08-5d83-b497-1cbe4ae6fcfe
DOI: 10.21203/rs.3.rs-4639630/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Luteolin attenuate paraquat-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathwayDOI 10.21203/rs.3.rs-4639630/v1Read

Exploring the mechanism of astaxanthin against lipopolysaccharide-induced acute lung injury by network pharmacology and experimental validationSemantic proximity Read

Identification of Hub Genes and Key Pathways of Paraquat Induced Human Embryonic Pulmonary Fibrosis by Bioinformatics Analysis and Vitro ExperimentsSemantic proximity Read

Paraquat Modulates Immunological Function in Bone Marrow-Derived MacrophagesSemantic proximity Read

Mechanistic Analysis of Luteolin in Mitigating Dry Age-Related Macular Degeneration through Network Pharmacology and Experimental ValidationSemantic proximity Read

Resveratrol and Quercetin Protect From Benzo(a)pyrene-induced Autophagy in Retinal Pigment Epithelial CellsSemantic proximity Read

Inhibition of Lipid Accumulation in NAFLD Liver by Extract of Rosa laevigata Fruit Extract through Activation of the PI3K-AKT Signaling PathwaySemantic proximity Read

Combined Signaling of NF-kappaB and IL-17 Contributes to Mesenchymal Stem Cells-Mediated Protection for Paraquat-induced Acute Lung InjurySemantic proximity Read

Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer CellsSemantic proximity Read

Quercetin activates autophagy suppresses apoptosis, inflammation and cartilage matrix degradation in LPS-induced chondrocytes through targeting AMPK/mTOR/ULK1 signaling pathwaySemantic proximity Read

Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptorsSemantic proximity Read

Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy inductionSemantic proximity Read

Kaempferol reversals retinal ischemia/reperfusion (IR) injury through activating of PI3K/Akt/mTOR signaling pathwaySemantic proximity Read