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EBV promotes tumorigenicity and worsens the prognosis of Hodgkin lymphoma through the expression of survival enhancing proteins by activating the JAK / STAT and NF-kB signaling pathways. (A comparative study between EBV positive and negative Hodgkin lymphoma)

2022-07-27

Abstract excerpt

<h4>Background: </h4> Epstein-Barr virus (EBV) is involved in 40% of all Hodgkin's lymphoma (HL) cases. EBV produces epigenetic alterations in the host genome that decrease the expression of proapoptotic proteins and activate the expression of survival immortalization genes. Methods According to EBNA-1 detection by nested PCR, 64 patients with HL were classified into two groups: EBV positive and negative HL. The...

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Literature Corpus work
5fc8db85-ce5b-5f48-80b3-b4e98fc38904
DOI
10.21203/rs.3.rs-1857436/v1
Open publication

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EBV promotes tumorigenicity and worsens the prognosis of Hodgkin lymphoma through the expression of survival enhancing proteins by activating the JAK / STAT and NF-kB signaling pathways. (A comparative study between EBV positive and negative Hodgkin lymphoma)DOI 10.21203/rs.3.rs-1857436/v1
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