Article
Helicobacter pylori infection upregulates miR-135b-5p to stimulate gastric cancer cell proliferation and inhibit cell apoptosis through activated IL-6/STAT3 signaling
2022-08-03
Abstract excerpt
<h4>Background: </h4> Helicobacter pylori ( H. pylori ) infection is a strong pathogenic factor of gastric cancer (GC). The dysregulation of microRNAs (miRNAs) has been correlated with gastric tumorigenesis, but their role in H. pylori -induced GC remains inadequately evaluated. Methods In situ hybridization was performed for evaluation of miR-135b-5p expression in GC patients. MTS assay, EdU cell imaging assay,...
Topics
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- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- MicroRNA in disease regulation
Identifiers and source
- Literature Corpus work
- 5f97ff7d-0a11-5e8c-b07a-6ec02a6dfd6f
- DOI
- 10.21203/rs.3.rs-1906435/v1
