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Localization and RNAi-driven inhibition of a <i>Brugia malayi</i> encoded Interleukin-5 Receptor Binding protein

2021-05-14

Abstract excerpt

A molecule termed BmIL5Rbp (aka Bm8757) was identified from Brugia malayi filarial worms and found to competitively inhibit human IL-5 binding to its human receptor. After the expression and purification of a recombinant BmIL5Rbp and generation of BmIL5Rbp-specific rabbit antibody, we localized the molecule on B. malayi worms through immunohistochemistry and immunoelectron microscopy. RNA interference was used...

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Identifiers and source

Literature Corpus work
5f40797b-4b43-52f5-8893-839cb8303d56
DOI
10.1101/2021.05.13.443627
Open publication

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Localization and RNAi-driven inhibition of a <i>Brugia malayi</i> encoded Interleukin-5 Receptor Binding proteinDOI 10.1101/2021.05.13.443627
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