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Article

Addition of losartan to FOLFORINOX and chemoradiation downregulates pro-invasion and immunosuppression-associated genes in locally advanced pancreatic cancer

2022-06-13

Abstract excerpt

<h4>Purpose</h4> Adding losartan to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechanisms of benefit by assessing the effects of neoadjuvant losartan+FFX+CRT versus FFX+CRT on the stromal tumor microenvironment. <h4>Experimental Design</h4> We perfor...

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Identifiers and source

Literature Corpus work
5eaaf253-c6fb-580f-b4a5-9a01adfe7c99
DOI
10.1101/2022.06.09.22275912
Open publication

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Addition of losartan to FOLFORINOX and chemoradiation downregulates pro-invasion and immunosuppression-associated genes in locally advanced pancreatic cancerDOI 10.1101/2022.06.09.22275912
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