Article

Methods and Operational Framework of the GALFLU Pragmatic Trial: Design and Feasibility of an Individually Randomized Controlled Trial Evaluating High-Dose Versus Standard-Dose Influenza Vaccination in Older Adults

2025-07-25

Abstract excerpt

<h4>Background</h4> Optimizing influenza vaccination in older adults is a public health priority. While high-dose inactivated influenza vaccines (HD-IIV) have shown superior immunogenicity and efficacy over standard-dose vaccines (SD-IIV), there is a shortage of large-scale, individually randomized data evaluating real-world effectiveness against severe outcomes—especially within publicly funded health systems. <...

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Literature Corpus work: 5e85061b-29ae-5287-97ec-d951c694b92c
DOI: 10.1101/2025.07.24.25332041

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Methods and Operational Framework of the GALFLU Pragmatic Trial: Design and Feasibility of an Individually Randomized Controlled Trial Evaluating High-Dose Versus Standard-Dose Influenza Vaccination in Older AdultsDOI 10.1101/2025.07.24.25332041Read

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