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Article

A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression.

Mucosal immunology - 1 Mar 2013

Settem R P, Honma K, Nakajima T, Phansopa C, Roy S, Stafford G P, Sharma A

Abstract excerpt

Tannerella forsythia is a pathogen implicated in periodontitis, an inflammatory disease of the tooth-supporting tissues often leading to tooth loss. This key periodontal pathogen is decorated with a unique glycan core O-glycosidically linked to the bacterium's proteinaceous surface (S)-layer lattice and other glycoproteins. Herein, we show that the terminal motif of this glycan core acts to modulate dendritic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22968422
DOI: 10.1038/mi.2012.85
PMCID: PMC4049606

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